Do Online Canadian Pharmacies Require a Prescription? The attitude to the sales of drugs at Canadian pharmacy canadianpharmrx is quite the same as that of traditional drugstores. Just like usual, Canadian online pharmacies require a prescription in order to get a prescription medication. It needs to be signed by a qualified medical practitioner. However, the good news is that only legal pharmacies ask for a prescription so this is your best guarantee of the legitimacy of the given company.